Causes Of Elevated Levels B12

Causes Of Elevated Levels B12

Elevated levels of B12 are rare and often caused by disease, usually hepatic dysfunction or disease in blood. According to the Mayo Clinic, “Vitamin B12 or cobalamin, helps nerve cells, red blood cells and used in the creation of DNA.” Over-production of Vitamin B12 can be caused by cirrhosis, hepatitis, polycythemia vera or myelocytic leukemia. Vitamin B12 supplements will not cause elevated B12 in the blood.
cirrhosis
Elevated levels of B12 can be caused by cirrhosis, scarring of the liver. Hepatic function corresponds to elevated B12 levels because the liver can not maintain B12 properly and the rest are spread throughout the body. A 2003 study published in “Clinical Biochemistry” Amphi Hospital in Lokatie Langendijk, Breda, Netherlands, found association between high B12 levels and people with cirrhosis. According Amphi Hospital study, “elevated levels are caused by cobalamin release under reduced cytolysis and / or decreased cobalamin cleared with the affected liver.”
hepatitis
Hepatitis, a disease that damages the liver may lead to an increase in cobalamin, which, according to the National Institutes of Health, is typically stored in the liver for years. Untreated, hepatitis potential to go away, or it can lead to liver failure or cancer. It also has the potential to turn into cirrhosis.
Chronic leukemia Myelocytic
Chronic myelocytic leukemia or CML is a cancer of the bone marrow that has been associated with elevated B12 levels. According to “American Journal of Clinical Nutrition,” the excess of B12 in them with CML may be caused by “serum protein binding B12 more than liver proteins, or lack of B12 transferase and increased binding of serum proteins. “This could be the reason for B12 to be incorrect absorbed into the body.
polycythemia vera
Polycythemia vera is a disease characterized by overproduction of red blood cells. 2003 study published in “Clinical Biochemistry” Amphi Hospital in Lokatie Langendijk, Breda, Netherlands, found elevated B12 levels in polycythemia vera patients. Those with polycythemia vera can not bind vitamin B12 properly, causing a supersaturation of cobalamin. A B12 blood test to find elevated B12 levels can tell if someone has polycythemia vera. Polycthemia vera can result in myelofibrosis, a disease that is characterized by a decrease in white blood cells, red blood cells and platelets. Testing for elevated B12 levels in those with myelofibrosis will also return positive.

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